Details for gene set BIOCARTA_THE CO-STIMULATORY SIGNAL DURING T-CELL ACTIVATION[GSEA]

Table: GSEA Results Summary

Dataset	Set_03_absentNotch_versus_normalThy.phenotype_absentNotch_versus_normalThy.cls #absentNotch_versus_normalThy.phenotype_absentNotch_versus_normalThy.cls #absentNotch_versus_normalThy_repos
Phenotype	phenotype_absentNotch_versus_normalThy.cls#absentNotch_versus_normalThy_repos
Upregulated in class	normalThy
GeneSet	BIOCARTA_THE CO-STIMULATORY SIGNAL DURING T-CELL ACTIVATION
Enrichment Score (ES)	-0.88152987
Normalized Enrichment Score (NES)	-1.5544965
Nominal p-value	0.00862069
FDR q-value	0.21206161
FWER p-Value	0.862

Table: GSEA details [plain text format]
	PROBE	DESCRIPTION (from dataset)	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	GRB2	6650398	1188	0.612	-0.0273	No
2	CD80	870112	2380	0.226	-0.0779	No
3	CD86	3390471 6200280	4662	0.032	-0.1986	No
4	PTPN11	2230100 2470180 6100528	7257	0.008	-0.3376	No
5	PIK3R1	4730671	7437	0.007	-0.3467	No
6	PIK3CA	6220129	12684	-0.010	-0.6282	No
7	CTLA4	6590537	14189	-0.026	-0.7075	No
8	ICOSLG	70128	14481	-0.032	-0.7212	No
9	ICOS	1190048	16128	-0.161	-0.8001	No
10	LCK	3360142	17548	-0.561	-0.8428	Yes
11	CD3E	3800056	18269	-1.267	-0.8058	Yes
12	CD3D	2810739	18272	-1.277	-0.7297	Yes
13	CD28	1400739 4210093	18406	-1.672	-0.6370	Yes
14	ITK	2230592	18426	-1.732	-0.5345	Yes
15	CD247	3800725 5720136	18457	-1.820	-0.4274	Yes
16	CD3G	2680288	18531	-2.468	-0.2839	Yes
17	TRB@	3940292	18610	-4.828	0.0003	Yes

Fig 3: BIOCARTA_THE CO-STIMULATORY SIGNAL DURING T-CELL ACTIVATION: Random ES distribution
Gene set null distribution of ES for BIOCARTA_THE CO-STIMULATORY SIGNAL DURING T-CELL ACTIVATION